IGERT Home Training Group Thematic Basis Fellowships NSF IGERT National Recruitment Program NSF IGERT Funding Research Areas: Bioinformatics Genome Evolution Genomics Macromolecular Structure & Function		Macromolecular Structure & Function Overview Project director Co-PI Susan Carpenter Veterinary Microbiology and Preventive Medicine CMB faculty members are using multiple, complementary approaches to understand macromolecular structure/function relationships. Several participants are utilizing the wealth of information that can be extrapolated by tracing patterns of evolutionary change. One project builds upon the work of three CMB faculty members (Carpenter, A. Miller, Voytas) who have interests in virus and transposable element biology, particularly the many protein and protein-nucleic acid interactions that regulate virus or transposon gene expression and replication. Participants in this research project are trying to discern molecular functional and structural information from natural variability observed among viral or transposable element populations. More recently, these studies have benefited from collaborations with members of the molecular modeling group (Cornette, Ho, Ashlock) and structural biologists (Andreotti, Hargrove). CMB faculty also have interests in molecular modeling, and they meet weekly to discuss problems of protein structure prediction. Among these are participants from physics (Ho), computer science (L. Miller, Honavar), mathematics (Ashlock, Cornette) and the biological sciences (Andreotti, Hargrove, Honzatko, Dobbs and Naylor). This group exemplifies the interdisciplinary interactions that have emerged among CMB training group participants over the past year.
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